Associations of serum vitamin D and Fok I polymorphism of receptor gene with unexplained recurrent spontaneous abortion

Abstract Background : To investigate the associations of serum vitamin D and Fok I polymorphism its receptor (VDR) with unexplained recurrent spontaneous abortion (URSA). Methods Ninety URSA patients another 104 healthy pregnant women were selected as control groups, respectively. 25-Hydroxyvitamin [25-(OH)D] level was detected by chemiluminescence. VDR gene analyzed PCR, distribution genotype frequency calculated Hardy-Weinberg equilibrium test. Association between susceptibility to investigated logistic regression analysis. Results Gestational age, uterine height, waist circumference, 25-(OH)D proportions FF Ff genotypes significantly lower in group (P<0.05). Compared ff genotype, risk reduced for genotypes. allele f, F. group, which than that >30 ng/mL F (FF+Ff), increased 2.45-, 2.43- 5.34-fold those ≤30 ng/mL, Conclusions The normal women. Probably, is associated occurrence, decreases risk. dramatically increases deficiency.